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Author

Tong-Yu Zhu

2 papers indexed here

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Review Open access Aug 2026

Lactylation at the crossroads of metabolism and immunity in renal injury and transplant rejection.

Lactate, once regarded merely as a metabolic waste product of glycolysis, has recently emerged as a potent signaling molecule and regulator of cellular function. The discovery of protein lactylation, a novel post-translational modification derived from lactate metabolism, has revealed a critical mechanism linking metab...

Boyang Yu, Yufeng Zhao, Jiaheng Wu et al. · 0 citations
Review Sep 2026

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction.

SIGNIFICANCE Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because their antimicrobial functions depend on tig...

Rui-Rui Shi, Si-Yue Chen, Ting-Ting Chen et al. · 0 citations

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