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Author

Toshiyuki Kakumoto

2 papers indexed here

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Aug 2026

Subthreshold early white-matter hyperintensity increase predicts accelerated hippocampal and whole-brain atrophy in anti-amyloid-β immunotherapy

Background Anti-amyloid-β (anti-Aβ) therapy slows cognitive decline but paradoxically accelerates whole-brain gray matter atrophy, complicating outcome prediction. Objective To identify early imaging markers that predict long-term prognoses. Methods This longitudinal cohort study prospectively enrolled participants wit...

Shiori Amemiya, Hidemasa Takao, Shoya Matsumoto et al. · 0 citations
Open access Jul 2026

A Case of Distal Hereditary Motor Neuronopathy‐7 With Two Novel VWA1 Variants in Compound Heterozygosity

Distal hereditary motor neuronopathy‐7 (HMNR7) is an autosomal recessive VWA1‐related disorder characterized predominantly by distal motor involvement. A 41‐year‐old man with a history of childhood orthopedic surgery for foot deformities exhibited progressive distal weakness and muscle atrophy with lower limb predo...

Toshiyuki Kakumoto, Kenta Orimo, T. Matsukawa et al. · 0 citations

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