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Author

Tsu-Kung Lin

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Open access Sep 2026

Mitochondrial DNA Haplogroups Influence Oxidative Stress Profiles and Susceptibility to Metabolic Syndrome in an Asian Population

Mitochondrial DNA (mtDNA) haplogroups influence mitochondrial function and reactive oxygen species (ROS) production, potentially modulating susceptibility to metabolic disorders. This study investigated the associations between mtDNA haplogroups, systemic oxidative stress, and metabolic syndrome in 2486 Taiwanese indiv...

Shao-Wen Weng, Yu-Han Lin, Shi-Huo Chen et al. · 0 citations
Sep 2026

Inhibition of STING Protects the Neuroretina in an Ndufs4 Knockout Mouse Model of Mitochondrial Complex 1 Deficiency.

PURPOSE Ndufs4 encodes a key subunit of mitochondrial complex I, and its mutation causes NADH dehydrogenase deficiency associated with Leigh syndrome and Leber hereditary optic neuropathy. In Ndufs4 knockout (KO) mice, vision loss occurs alongside an "inflammatory wave" that disrupts neuroretinal function. In this stud...

Jong-Jer Lee, Yu-Ting Hsiao, Hsiu-Mei Huang et al. · 0 citations

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