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Tsukasa Kobayashi

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Oct 2026

Metabolic profile of thiopental and cytochrome P450-mediated drug interactions in rats.

1. Pentobarbital (PTB) is metabolised by cytochrome P450 (CYP) enzymes, being a model compound for evaluating CYP-mediated drug-drug interactions, has become difficult to obtain for animal studies in Japan. The metabolic pathway of thiopental (TP), a barbiturate with similar pharmacological properties, remains insuffic...

Tsukasa Kobayashi, Y. Takeba, Kouichi Sugaya et al. · 0 citations

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