Tun Liu

Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head

Summary Cartilage degeneration in osteonecrosis of the femoral head (ONFH) is closely associated with chondrocyte heterogeneity. Single-cell RNA sequencing was performed on 50,851 chondrocytes from 10 ONFH patients and 10 controls. The findings were further validated using an in vitro chondrocyte injury model induced b...