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Author

Tyce J. Kearl

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Open access Aug 2026

Pre-treatment polyfunctionality percentage (PFA) of CD8+ T cells is associated with development of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICIs)

Introduction Immune checkpoint inhibitors (ICIs) have improved cancer survival, but immune-related adverse events (irAEs) occur frequently and can have devastating consequences. There are no validated methods to evaluate risk of irAEs prior to initiation of ICIs. Materials and Methods We conducted a pilot study evaluat...

Jonathan Thompson, Katie A. Palen, S. Menon et al. · 0 citations
Sep 2026

Targeting CD38 with bispecific antibody XmAb 18968 in patients with relapsed/refractory acute myeloid leukemia and T-cell acute lymphoblastic leukemia.

XmAb18968 is safe and tolerable with encouraging preliminary efficacy, supporting further investigation of CD38 targeting therapies in this setting, and further investigation of CD38 targeting therapies in this setting is supported.

G. S. Guru Murthy, B. Shah, Talha Badar et al. · 0 citations
Open access Jul 2026

CAR-T with ICOS costimulation lacks therapeutic efficacy in patients due to strong trogocytosis and failure of expansion 2261203

The ICOS domain promotes trogocytosis and fratricide, explaining the poor persistence and function of ICOS CAR-T cells observed in this trial and raise significant caution for using CAR constructs that rely on ICOS for CAR activation.

Yongxia Wu, Allison Pugel, Katie A. Palen et al. · 0 citations

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