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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Tyler Jacks

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Jul 2026

MHC-II-restricted neoantigen expression drives tumor infiltration, activation, and maintenance of nonspecific T cells in lung cancer 2251169

Cancer mutations can result in the expression of tumor-specific “neoantigens” that are targeted by T cells. Neoantigen expression drives robust T cell infiltration of tumors across cancer models, yet most of these T cells are not specific for the neoantigens and contain both pathogenic and immunosuppressive subse...

D. Klawon, Shalom Beyene, Jacob Kassama et al. · 0 citations
Jul 2026

Neoantigen-specific CD4+ T cells sustain endogenous intratumoral B cell responses to enhance anti-tumor immunity 2258511

Cancer mutations can give rise to novel tumor-specific peptides (“neoantigens”) that are recognized by T cells to attack tumors. CD4+ T cells cooperate with B cells of related antigen specificity to promote antibody production and enhance antitumor immunity. Paradoxically, tumors are frequently coated with mature...

D. Klawon, Shalom Beyene, Sean-Luc Shanahan et al. · 0 citations

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