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Three distinct phenotypic clusters were identified, each with heterogeneous clinical characteristics and outcomes, underscoring the need for more individualised, phenotype-informed management strategies in this complex patient population.
The GLORIA-AF Bleeding Score showed modestly higher discrimination than HAS-BLED for 1-year major bleeding prediction while retaining clinical interpretability and usability and external validation in independent European and Asia-Pacific registries further supports its transportability beyond the derivation population...
External validation of the GLORIA-AF Stroke Weighted Risk Score supports its transportability and potential adjunctive role in guideline-directed thromboembolic risk assessment and generally greater net benefit than CHA2DS2-VA.
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