Pyridoxine and valproic acid co-exposure induces ER-mediated calcium dysregulation and cardiac toxicity in zebrafish.
Vitamin supplements are frequently utilized as adjunctive therapies in epilepsy care, yet the potential for toxic drug-nutrient interactions remains poorly defined. Using a pentylenetetrazol (PTZ) zebrafish seizure model, we conducted an exploratory screening of a multivitamin formulation containing vitamins B6, B9, D3...