Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially) present with predominant or isolated ps...
D. Endres, K. von Zedtwitz, Ludger Tebartz van Elst et al.· Molecular Psychiatry· 0 citations
Depressive symptoms show an increased prevalence in individuals affected by spinal cord injury (SCI), yet their in-depth characterization and association with clinical outcomes remain underexplored. We investigated depressive symptoms, operationalized through the items in the Beck Depression Inventory (BDI), in a longi...
Roman Schefzik, L. Heutehaus, C. Schuld et al.· Scientific Reports· 0 citations
BACKGROUND
Negative expectations towards the future are frequently observed in patients with major depressive disorder (MDD) and linked to less favourable outcomes like worse treatment response and suicidal behaviours. Despite clinical significance, the neurobiological underpinnings of negative expectations remain larg...
Laila Noor, F. Stein, K. Brosch et al.· Journal of Affective Disorde...· 0 citations
Negative biases in emotional processing are central to cognitive models of Major Depressive Disorder (MDD), yet it remains unclear whether negatively biased valence attribution covaries with depressive symptoms or represents a more stable vulnerability. In this longitudinal study, we examined emotional valence ratings...
Katharina Hierl, Liane Wollweber, H. Lemke et al.· Journal of Affective Disorde...· 0 citations
It is suggested that cumulative illness burden is a key factor associated with brain structural decline in MDD, while also suggesting potential reversibility in more favorable disease courses.
A. Kraus, J. Goltermann, T. Borgers et al.· JAMA Network Open· 0 citations
This work systematically characterize the electrophysiological signatures of prolonged wakefulness using a multi-methodological approach and identifies robust cross-species biomarkers of sleep pressure, potentially enabling personalized chronotherapeutic interventions for psychiatric disorders.
Thomas Kroker, L. Puder, O. Abbasi et al.· bioRxiv· 0 citations
The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.
M. Gruber, Henrike Renaud, M. Mauritz et al.· Psychotherapy and Psychosoma...· 0 citations
Disruptions in the hierarchical organization of brain functional networks in patients with psychotic and affective disorders indicate deficits in functional integration across psychiatric diseases, highlighting the role of attentional and sensory networks in disease processes.
J. Kambeitz, Hannah Hacker, L. Hoheisel et al.· Research Square· 0 citations
Social anxiety disorder (SAD) is a common anxiety disorder (ANX) with moderate heritability that often co-occurs with other mental disorders. Until now, sample sizes in genetic analyses of SAD have been limited, so that the genetic basis of SAD and its subphenotypes is still largely unknown. In a large cohort comprisin...
L. Sindermann, Angelina Röhrig, F. David et al.· Translational Psychiatry· 0 citations
Disruptions in the hierarchical organization of brain functional networks in individuals with psychotic and affective disorders indicate deficits in functional integration across psychiatric diseases, highlighting the role of attentional and sensory networks in disease processes.
Hannah Hacker, L. Hoheisel, M. Buciuman et al.· Translational Psychiatry· 0 citations
This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.
L. Fehse, A. H. Ribeiro, N. Winter et al.· Gut microbes· 0 citations
It is found that standard benchmarks do not adequately capture the strengths of the dataset, but expert judgment shows that SQPsych makes LLMs significantly better at therapist roleplaying.
Doan Nam Long Vu, Rui Tan, L. Mary Moench et al.· arXiv.org· 5 citations· ⚡2
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