Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5 + Intestinal Stem Cells
Tae-Hee Kim, A. Saadatpour, G. Guo et al.
· 0 citations
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Open access
Oct 2026
CDX2 Drives Divergent Regional Programs During Intestinal Development and Redeploys Them During Regeneration
It is shown that CDX2, despite uniform expression across the fetal and adult intestinal epithelium, organizes a hierarchical enhancer network that resolves into region-specific programs upstream of regional TFs.
A. Lorzadeh, G. Ye, M. Romero-Wolf et al.
· bioRxiv · 0 citations
Open access
Sep 2026
CDX2 Drives Divergent Regional Programs During Intestinal Development and Redeploys Them During Regeneration
Region-specific transcription factors (TFs) establish small intestinal and colonic identity, yet what activates their region-specific expression during development is unresolved. Moreover, discrete fetal gene sets reactivate during post-injury regeneration, but their full scope, and what reactivates the programs requir...
A. Lorzadeh, G. Ye, M. Romero-Wolf et al.
· bioRxiv · 0 citations