Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality worldwide, necessitating novel biomarkers and therapeutic targets. Irisin, a myokine derived from FNDC5, has emerged as a molecule of interest owing to its pleiotropic effects, yet its role in cardiovascular health is debated amid con...
S. Dabravolski, S. Shityakov, Nikita A. Mitkin et al.· Current Issues in Molecular...· 0 citations
This narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in apolipoprotein B-100 is considered, and the enzymes of the sialid...
Tatyana I. Kovyanova, V. P. Karagodin, D. Borodko et al.· Biomolecules· 0 citations
as it enhances brain energy metabolism and diminishes oxidative stress. Likewise, another investigation revealed that RV possesses anti-inflammatory and antioxidant characteristics. These properties can help suppress or prevent age-related cardiovascular diseases. Notably, RV has been shown to enhance cardiac contracti...
A. V. Poznyak, S.M. Kozlov, Gulalek A. Babayeva et al.· OnLine Journal of Biological...· 0 citations
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide, driven by complex interactions among dyslipidemia, chronic inflammation, insulin resistance, endothelial dysfunction, and gut microbiome-derived metabolites. This review synthesizes mechanistic and clinical ev...
Tatyana I. Kovyanova, M. Nerush, V. P. Karagodin et al.· Biomedicines· 0 citations
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