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Author

U. Schwartz

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Open access Sep 2026

Spn1 Maintains Nucleosome Organization at Transcription End Sites

Background/Objectives: Transcription by RNA polymerase II (RNAPII) occurs within chromatin and requires continuous disassembly and reassembly of nucleosomes. Histone chaperones associate with RNAPII, facilitate transcription, and maintain nucleosome organization. This study investigated the role of the conserved histon...

U. Schwartz · 0 citations
Open access Sep 2026

Proteasome inhibition alleviates proteinuria in Lmx1b knock-in mice with dysfunctional LIM domains

Proteasomal inhibitors, drugs already approved for treatment of patients with multiple myeloma, warrant further studies to prevent renal failure in patients with nail-patella syndrome caused by mutations in the LIM domains, providing proof of principle for a novel therapeutic strategy.

Joshua Hermens, Lisa Lucke, O. Pieles et al. · 0 citations
Open access Aug 2026

The SWI/SNF subunit SWI3B functions with the m6A writer complex to establish embryo patterning in Arabidopsis

A mechanism by which chromatin remodeling and m6A-mediated RNA regulation cooperate to suppress the precocious stability of key developmental regulators, thereby contributing to the establishment of the transcriptional program required for early embryo patterning in Arabidopsis is uncovered.

Wen Gong, U. Schwartz, L. Fu et al. · 0 citations

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