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Sep 2026

Individual and Cumulative Impacts of Diagnosis-to-Treatment Interval and Radiotherapy Interval on Survival in Nasopharyngeal Cancer.

OBJECTIVE To evaluate the impact of diagnosis-to-treatment interval (DTI) and radiotherapy interval (RTI) on overall survival (OS) in locally advanced nasopharyngeal carcinoma (LA-NPC) treated with concurrent chemoradiotherapy (CCRT). STUDY DESIGN Retrospective database study. SETTINGS Single tertiary academic cent...

E. Topkan, E. Somay, S. Başçıl et al. · 0 citations
Open access Aug 2026

Clinicopathologic and molecular characteristics of colorectal cancer patients with brain metastases: a multicenter cohort study

Brain metastases (BM) from colorectal cancer (CRC) are uncommon but clinically consequential. We characterized clinicomolecular features of CRC patients with BM and evaluated the prognostic impact of BM timing. We screened CRC patients treated/followed between 2015 and 2024 and included those with radiologically confir...

F. Kemik, B. Köylü, C. Kıkılı et al. · 0 citations
Open access Aug 2026

BRD9 inhibition induces selective radiosensitivity in glioblastoma through MYC pathway modulation

Radiotherapy (RT) is a cornerstone of glioblastoma (GBM) treatment, yet therapeutic resistance remains nearly universal due to the rapid activation of stress-adaptive survival programs. Identifying molecular regulators that sustain these adaptive responses may reveal context-dependent vulnerabilities that can be therap...

Nareg Degirmenci, S. A. Celikkol, B. N. Koseoglu et al. · 0 citations

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