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Review Open access Oct 2026

Conceptualising Bailan (摆烂): A Narrative Review of Cultural Disengagement, Psychosocial Distress, and Potential Clinical Risk

Bailan (摆烂), meaning “to give up and let things rot,” has emerged among Chinese youth as a cultural expression of disillusionment, withdrawal, and resignation in response to intense academic, occupational, and socioeconomic pressures. However, its conceptual boundaries and clinical relevance remain unclear. This narr...

N. Pang, U. Volpe, L. Orsolini et al. · 0 citations
Review Open access Aug 2026

Long-Acting Injectable Antipsychotics in Schizophrenia and Comorbid Substance Use Disorder: A Systematic Review of the Literature

The present review suggests that LAIs may represent a valuable therapeutic strategy for patients with schizophrenia and comorbid SUD, although the available evidence remains heterogeneous in terms of study design, patient populations, and outcome measures.

Matteo Lupi, A. Carano, Eros Rossi et al. · 0 citations
Open access Sep 2026

From real-world experience to precision prescribing of antidepressants: a machine-learning analysis of clinicians' treatment choices.

This study examined whether psychiatrists' routine prescribing decisions could be used to identify practice-grounded patterns supporting precision-oriented treatment selection, and found that similarity-based models may provide a more conceptually coherent approach.

Francesco Calabró, Claudio Caiazza, U. Albert et al. · 0 citations
Open access Sep 2026

Predicting early psychiatric readmission among people with major depressive disorder: A machine learning analysis from the prospective multicentre DEEP READ study.

These findings suggest that standard clinical variables may hold predictive value for early readmission in MDD, however, external validation, assessment of model calibration, and clinical utility are needed prior to clinical implementation.

F. Bartoli, M. Luciano, C. Crocamo et al. · 0 citations
Open access Aug 2026

Differential associations of inflammatory-metabolic markers with depressive symptom dimensions: Towards a clinical phenotyping of immune-metabolic depression.

BACKGROUND Depression is increasingly conceptualized as a biologically heterogeneous condition, with immune-inflammatory and metabolic dysregulation implicated in specific symptom dimensions rather than overall depressive severity. However, it remains unclear whether different combinations of inflammatory and metabolic...

M. Di Nicola, M. Pepe, A. Aguglia et al. · 0 citations

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