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Author

Umesh R. Desai

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Open access Sep 2026

A Synthetic, Small Molecule, Allosteric Inhibitor of Human Factor XIa for Thrombosis.

Only a handful of anticoagulants have reached the clinic to treat and prevent thrombotic episodes in the millions of patients suffering from cardiovascular, cancer, viral (COVID-19) and metabolic diseases. In this work, we report the discovery, chemical synthesis, mechanistic biochemistry, pharmacology, and toxicology...

Chiranjeev Sharma, Rama Gunta, Sridhar R. Iyer et al. · 0 citations

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