Abstract Introduction Neuropathic pain is a chronic and debilitating condition characterized by maladaptive changes in peripheral and central nervous system pathways. It is driven by abnormal neuronal excitability and excitatory neurotransmission. Among the key contributors are voltage-gated sodium channels (VGSCs) and...
Utpal Bhui, Radheshyam Pal, Amit Chakraborty et al.· Drug Metabolism and Personal...· 0 citations
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are key microbial metabolites generated through the fermentation of indigestible carbohydrates by gut bacteria. Beyond their local actions in the intestinal environment, these metabolites exert far-reaching systemic effects, particularly in s...
Harshpreet Kaur, Joy Das, A. Sah et al.· Current pharmaceutical desig...· 0 citations
Summary Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal growth and maturation, as well as in maintaining synaptic plasticity. Dysregulated BDNF levels significantly increase the risk of neurological and metabolic disorders. In type 2 diabetes mellitus, several pathological mechanisms, inclu...
Garima Chandak, B. Kumar, Shubham Kumar et al.· iScience· 0 citations
This review focuses on a targeted introduction of the herbal nanocarrier-based treatment approach for liver diseases and the correlation between the various properties of the nanocarrier and the enhancement effect of the plant-derived compounds’ delivery in the liver.
Utpal Bhui, S. Sen, Sudipta Roy et al.· Journal of Medicinal Natural...· 0 citations
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