SAILR is identified as a central regulator in linking macrophage survival to host-pathogen interaction and disease pathophysiology, and interacts with the antiapoptotic adaptor protein 14-3-3β to support macrophage survival.
A. Westermann, Alexandra Schock, Diyaa Al Din Ashour et al.· Proceedings of the National...· 2 citations
These findings establish YqeK as a central regulator of dinucleotide homeostasis and RNA metabolism and provide the structural framework for Ap4N recognition by HD-domain phosphohydrolases.
Renuka Dharani Shivakumar, Natalie Happel, Fabiana Burchert et al.· Journal of Biological Chemis...· 0 citations
N-hydroxyapiosporamide (NHAP) is established as a first-in-class Gi-selective inhibitor, providing a cell-permeable chemical scaffold for the optimization of next-generation agents to control Gi-signaling in cell-based systems and, ultimately, to target Gαi1-driven pathologies.
A. Naimi, Tim Berger, Philipp Dahlhaus et al.· bioRxiv· 0 citations
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