Open access
Aug 2026
Prognostic stratification by LGR5 expression identifies surface-accessible, structurally ligandable and condensate-forming targets in colorectal cancer
LGR5 expression defines a colorectal cancer subset that is pharmacologically tractable despite the absence of genetic dependency, including condensate-directed modulation of NKD1 as a route to targets inaccessible by antibody- or pocket-based approaches.
Lucía Paniagua-Herranz, A. Feito, Cristian Privat et al.
· bioRxiv · 0 citations