Adult T-cell leukemia/lymphoma (ATL) is associated with a dismal prognosis in aggressive subtypes, with a median overall survival (OS) of less than one year. In Japan, first line chemotherapy followed by allogeneic stem cell transplantation (allo-SCT) is recommended for eligible patients, yet this strategy is scarcely...
A. Marçais, L. Lhermitte, V. Avettand-Fenoel et al.· Blood Advances· 0 citations
Background Promoters have been traditionally seen as contiguous gene-adjacent cis-regulatory elements. Yet, substantial studies corroborate that Epromoters (promoters with enhancer activity) engage in distal forms of gene regulation. Although in the three-dimensional (3D) space enhancer-promoter networks have been well...
Joaquin Felipe Roca Paixão, I. Manosalva, A. Pinton et al.· bioRxiv· 0 citations
A transition in human thymopoiesis is suggested from an early effector‐prone unconventional output to predominantly conventional T‐cell production after 3 months, highlighting a critical window in immune system establishment.
C. Kergaravat, Jean-Marc Doisne, Clarisse Godard et al.· European Journal of Immunolo...· 0 citations
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