Author

V. D'Agostino

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Open access Oct 2026

Computational targeting of APE1-miRNA interactions in Cancer: Prioritization of candidate modulators.

Tumor development and resistance to therapy are influenced by adaptive transcriptional and post-transcriptional processes, including dysregulated miRNA biogenesis. APE1 participates in canonical DNA-repair and redox functions as well as non-canonical RNA-associated processes, making selective investigation of its RNA i...

G. Amera, G. Canarutto, Alessia Bellina et al. · Bioorganic chemistry (Print) · 0 citations

Open access Sep 2026

Inhibiting HuR-Mediated mRNA Stabilization Attenuates Psoriasis-Like Inflammation in Preclinical Models

Purpose Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferative keratinocytes and activated Th17/Th1 lymphocytes, which sustain a self-perpetuating cycle by releasing pro-inflammatory cytokines. The RNA-binding protein (RBP) Human Antigen R (HuR) stabilizes many of these cytokine mRNAs, con...

Dalila Paladino, C. G. Atene, Martina Paganin et al. · Psoriasis · 0 citations