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Author

V. Di Sarno

2 papers indexed here

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Open access Aug 2026

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators.

Kv7 voltage-gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally-expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerative diseases; thus, they represent attractive ther...

T. Ciaglia, G. Carleo, Zhenni Yang et al. · 0 citations
Open access Jul 2026

Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5‑LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis

Acute pancreatitis (AP) is a common, serious, pancreatic inflammation representing an unmet therapeutical need. Here, we report the design and synthesis of a series of compounds as dual 5-lipoxygenase (LOX)/soluble epoxide hydrolase (sEH) inhibitors aimed at favorably modulating inflammatory lipid mediator pathways. Th...

D. D’Avino, T. Ciaglia, P. M. Jordan et al. · 0 citations

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