V. Evola

Preoperative Frailty Predicts Mechanical Complications After Adult Spinal Deformity Surgery: A Retrospective Study

BACKGROUND AND OBJECTIVES: Adult spinal deformity (ASD) surgery is associated with high rates of mechanical complications, including rod fracture, pseudarthrosis, and implant failure. Although frailty has emerged as a superior predictor of adverse outcomes compared with chronological age or comorbidity burden alone, it...

Semaglutide as a potential neuroprotective agent for neurological and neurodegenerative disorders: Mechanisms, preclinical evidence, and translational challenges and opportunities