Sep 2026
Abstract B144: MUC16-directed DR5 activation by IMV-M induces selective tumor cell apoptosis and tumor regression and enhances the activity of KRAS inhibitors in preclinical pancreatic cancer models
Bispecific apoptosis triggers (BATs) are a novel class of bispecific antibodies designed to target both a tumor-associated antigen and death receptor 5 (DR5) that have shown improved efficacy and reduced toxicity compared to conventional DR5 antibody therapeutics in preclinical models. IMV-M is a novel bivalent BAT t...
Hai-Yong Han, M. Zucker, Sanjana Tripuraneni et al.
· Cancer Research · 0 citations