Breast cancer (BC) is the second most common cause of death in women. Current therapies like hormonal therapy, surgery, radiotherapy, and chemotherapy become ineffective due to severe side effects and multidrug resistance. Therefore, there is an urgent need for the development of more effective and safer anti-BC agents...
Soubhik Tanti, Akhilesh Gangwar, V. Jaitak· Archiv der Pharmazie· 0 citations
Pyrimidine-containing hybrids emerge as a privileged scaffold in medicinal chemistry for the development of effective, multitargeted anticancer agents with improved pharmacological profiles and reduced off-target effects.
Bhim Singh, Ankita Devi, V. Jaitak· Mini-Reviews in Medical Chem...· 0 citations
This research developed a promising lead molecule (HIT1) as a therapeutic approach for ER-positive breast cancer through pharmacophore model-based drug design of thiazine derivative targeting ERα via pharmacophore model-based drug design.
M. Sanjeev, Bhim Singh, Kailash Jangid et al.· Journal of Molecular Graphic...· 0 citations
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