Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy (CRL) is a rare microgliopathy, characterized by progressive neurodegeneration. Impaired STAT3 signaling reduces microglial numbers and limits their ability to clear cellular debris, leading to persistent inflammation and brain tissue damage that...
Most MS risk factors, including MS heredity, HLA-DRB1*15:01, Epstein-Barr nuclear antigen levels, smoking, and low sun exposure, were associated with both onset groups, with stronger effects in AOMS.
V. Karrenbauer, Tomas Olsson, L. Alfredsson et al.· Multiple Sclerosis· 0 citations
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