Gliosarcoma treatment remains a challenge due to its aggressiveness and high recurrence rates. This study describes the development and characterization of a novel hybrid drug delivery system (DDS) for localized photodynamic therapy (PDT). The system consists of a PVA/gelatin hydrogel encapsulated with hydroxyapatite m...
J. A. R. Ambrósio, J. A. Carvalho, Letícia G. M. Pinto et al.· ACS Omega· 0 citations
This study reports the development of a biodegradable poly(lactic acid) and gelatin (nPLA-G) bionanocomposite as a drug delivery system for chloroaluminum phthalocyanine (ClAlPc) in photodynamic therapy (PDT). Using a hybrid desolvation/emulsification technique, we engineered spherical nanoparticles with an average d...
J. A. Carvalho, J. A. R. Ambrósio, M. Beltrame et al.· ACS Omega· 0 citations
Glioblastoma multiforme is one of the most aggressive primary brain tumours and remains highly resistant to conventional therapeutic approaches. Photodynamic therapy has emerged as a promising alternative. However, the clinical application of many photosensitisers is limited by low stability, poor solubility, and non-s...
G. C. Gonçalves, Aveline Ventura, V. L. M. Marmo et al.· Photochemical and Photobiolo...· 0 citations
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