BACKGROUND AND OBJECTIVES
Idiopathic normal pressure hydrocephalus is a condition with gait impairment, incontinence, and cognitive decline, treated with shunt surgery. The Gothenburg scale (GBS) provides comprehensive assessment of symptoms and outcomes. The cerebrospinal fluid tap test (CSF-TT) is used as a prognosti...
A. Luikku, Henna-Kaisa Jyrkkänen, N. Danner et al.· Neurosurgery· 0 citations
Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibril...
Heikki E. M. Lukkarinen, A. Luikku, Antonios Dougalis et al.· Alzheimer's Research & T...· 0 citations
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
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