Open access
Sep 2026
555. Targeting kynurenine aminotransferase III: discovery of a selective and brain-penetrant inhibitor for reducing synthesis of immune-induced kynurenic acid
Abstract Background Kynurenic acid (KYNA) is a neuroactive metabolite produced via the kynurenine pathway. It acts as an endogenous N-methyl-D-aspartic acid (NMDA) receptor antagonist and is proposed to antagonize the α7-nicotinic acetylcholine receptor (α7nAChR). Elevated KYNA levels are observed in several conditions...
P. Fridh, Y. Gravenfors, L. Schwieler et al.
· International Journal of Neu... · 0 citations