Author

V. Lowe

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Open access Sep 2026

A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease

Key Points Question Can a harmonized visual reading framework enable reliable, tracer-agnostic staging of tau positron emission tomography (PET) pathology for clinical use? Findings In this multicenter cross-sectional study of 681 participants scanned with multiple tau PET radiotracers, a 5-class harmonized visual read...

E. Ruppert, M. Vermeiren, Marina Scop Medeiros et al. · JAMA Neurology · 0 citations

Open access Sep 2026

Pilot Multimodal Imaging Assessment of Neuropathological Iron Deposition and Molecular PET in Frontotemporal Lobar Degeneration

Background/Objectives: The role of iron in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) has been debated. However, the effects of iron on protein burden in these diseases remain poorly elucidated. We hypothesized that there is an association between iron deposition and tau and beta-amyloid depo...

Rodolfo Gabriel Gatto, Hossam Youssef, Gökhan Uruk et al. · Brain Science · 0 citations

Open access Sep 2026

Astrocyte reactivity identifies p-tau217-positive individuals at elevated risk of cognitive decline across the Alzheimer’s disease continuum

Plasma phosphorylated tau at threonine 217 (p-tau217) is a robust marker of Alzheimer’s disease (AD) pathology and progression. However, individuals positive for p-tau217 show substantial clinical heterogeneity, suggesting the influence of modifying biological processes. Here, we investigated whether plasma glial...

B. Bellaver, G. Povala, P. C. L. Ferreira et al. · Molecular Neurodegeneration · 0 citations