Author

Vasudevan Mani

3 papers indexed here

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Review Aug 2026

Biomarkers of Chemical- and Drug-Induced Neurotoxicity: A Review of Mechanistic Insights and Neuroprotective Strategies.

Chemical- and drug-induced neurotoxicity remains a concern in environmental health and clinical pharmacology due to the nervous system's vulnerability and limited regeneration. This review explores biomarkers for detecting, monitoring, and mitigating neurotoxicity, and discusses underlying mechanisms. It covers neuroto...

Abdulaziz Arif A. Alshammari, V. Mani · Food and Chemical Toxicology · 1 citation

Open access Sep 2026

Lamotrigine Attenuates Lipopolysaccharide-Induced Working-Memory Impairment and Is Associated with Changes in Neuroinflammatory, Oxidative-Stress, and Apoptosis-Related Markers

Background/Objectives: Persistent neuroinflammation, oxidative imbalance, and neuronal apoptosis are key mechanisms underlying memory loss and working-memory impairment in many neurodegenerative conditions. LTG, an established anticonvulsant recognized for its glutamate-modulating and immune-dampening actions, has been...

Bashair Hamed Alharbi, Abdulaziz Arif A. Alshammari, V. Mani · Brain Science · 0 citations

Open access Aug 2026

Design and synthesis of quinoline-derived thioureas as potential antihyperglycemic, anti-Alzheimer, and antioxidant agents

A library of quinoline-based thiourea hybrids 1–41 was synthesized via a single-step reaction scheme. All compounds were evaluated for their inhibitory potential against α-amylase, α-glucosidase, AChE, and BChE enzymes as well as for DPPH radical scavenging activity. Among forty-one compounds, 27–31 and 33–37 showed ex...

Faiza Seraj, Maryam Maqbool, F. Ali et al. · RSC Advances · 0 citations