Microglia are a population of central nervous system (CNS)-resident macrophages that play key roles in regulating CNS health. Emerging work has revealed a plethora of ways by which microglia monitor and regulate neuronal and glial function in homeostasis. In response to stressors, microglia lose these homeostatic fun...
Jonathan K. Monteiro, V. Miron· Molecular Neurodegeneration· 0 citations
Cognitive decline in aging impacts quality of life, for which therapeutic interventions are lacking. Why some individuals experience more severe cognitive decline with aging is unclear. Here we uncover a role for the brain's myelin-forming cells-oligodendrocytes-in explaining this variance. By investigating neuropathol...
Georgina A. Craig, Emeric Merour, L. Seeker et al.· Nature Medicine· 0 citations
Oligodendrocytes are a specialized class of glial cells responsible for myelination, which sustains central nervous system (CNS) function. Though long considered a passive and static cell, the oligodendrocyte is now recognized to actively support axonal energy demands through metabolic provision, modify neural signalin...
L. Ryan, V. Miron· Cell· 0 citations
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