V. Nicolini

PD-1-Targeted IL-2v Expands a Novel Stem-like T Cell Subset Distinct from Anti-PD-1 Therapy to Enhance Effector Differentiation

It is demonstrated that PD1-IL2v induces an early bifurcation in the differentiation of stem-like CD8⁺ T cells within tumor-draining lymph nodes, identifying an early branch point in stem-like T-cell differentiation and providing mechanistic insight into how PD1-IL2v circumvents exhaustion pathways to preferentially ge...