Open access
Sep 2026
Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response.
The DNA damage response (DDR) is a sophisticated network of cellular pathways whose perturbation leads to genome instability and is a key hallmark of oncogenesis. Here, we present data from 32 genome-scale loss-of-function CRISPR interference chemical-genetic screens with inhibitors targeting core constituents of the D...
T. O'Loughlin, A. Arab, Sara Misiukiewicz et al.
· Nature Chemical Biology · 0 citations