Review
Open access
Sep 2026
Nucleoporins in Cancer: Functional Roles and Therapeutic Opportunities
The nuclear pore complex (NPC) and its building-block proteins nucleoporins (NUPs) play fundamental roles in maintaining cellular fitness by regulating nucleocytoplasmic transport, chromatin and transcriptional activity, and genome stability. These core biological processes are critical for cancer cells, and thus tumor...
Perumalraja Kirthika, Vijayakumar Jawalagatti, M. Carceles-Cordon et al.
· Cancer Discovery · 0 citations