Author

V. S. Del Fiore

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Open access Aug 2026

Disruption of the TDP-43/RILP axis impairs autophagic flux and stress granule homeostasis

TDP-43 has many functions, including the regulation of autophagy and stress granule dynamics, and mutations in TDP-43 are causative of amyotrophic lateral sclerosis (ALS). Among these, the G376D mutation is associated with TDP-43 cytoplasmic mislocalization and mitochondrial and lysosomal dysfunctions. We discovere...

R. Romano, V. S. Del Fiore, Flora Guerra et al. · Cellular and Molecular Life... · 0 citations

Open access Aug 2026

Mitochondrial Quality Control Impairment Is a Hallmark of TDP-43G376D ALS Patient-Derived Fibroblasts

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder strongly associated with mitochondrial dysfunction and impaired proteostasis. Mutations in TARDBP, encoding TAR DNA-binding protein 43 (TDP-43), contribute to disease pathogenesis through cytoplasmic mislocalization and aggregation. Among t...

Giuseppe Petito, Maria Ventriglia, V. S. Del Fiore et al. · Antioxidants · 0 citations