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Clinical trial Oct 2026

Cobimetinib + Vemurafenib in Patients With BRAF V600E-Mutant Papillary Thyroid and Biliary Tract Cancers: Results From the TAPUR Study.

PURPOSE TAPUR is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer and genomic alterations. Results of two cohorts of patients with advanced thyroid (TC) or biliary tract cancer (BTC) with BRAF V600E mutations treated with cobimetinib pl...

Samantha A. Diamond-Rossi, M. Rothe, E. Garrett-Mayer et al. · 0 citations
Sep 2026

Abstract B003: Developing an all-human model of perineural invasion in pancreatic cancer

Perineural invasion (PNI), the infiltration of nerves by tumor cells, is a hallmark of pancreatic ductal adenocarcinoma (PDAC); however, despite being a clinically relevant phenomenon, the mechanisms underlying PNI remain poorly understood. Most currently available in vitro and ex vivo models rely on murine-sourced n...

Regina A. Casimiro-Núñez, Sydney Willey, Harrison L. Hiraki et al. · 0 citations

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