Bilayer Permeabilization and the ‘Sand-in-a-Gearbox’ Mechanism for Membrane-Active Molecules: Which Is Which?
Background/Objectives: Antimicrobial peptides are promising agents for combating resistant infections. They exhibit bactericidal activity against a wide range of microbes, primarily by disrupting the permeability of the bacterial membrane and ultimately causing cell death. Effective bacterial killing requires a high nu...