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Author

V. Smirnovas

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Oct 2026

Effect of freeze-thaw cycle induced oligomers on alpha-synuclein liquid-liquid phase separation and aggregation.

Protein aggregation in the form of amyloid fibrils is linked with the onset and progression of several widespread and incurable disorders, including neurodegenerative Alzheimer's and Parkinson's diseases. Despite decades of research and countless attempts to discover potential aggregation-altering treatment modalities,...

Kamilė Mikalauskaitė, Dominykas Veiveris, V. Smirnovas et al. · 0 citations
Open access Aug 2026

Impact of Lipid Composition and Synergistic Effect on Aβ42 Oligomer-Induced Changes in Membrane Conductance and Microviscosity

The results demonstrate that the presence of SM or GM1 within a DOPC/Chol backbone is enough to facilitate Aβ42 interaction with the membrane, as evidenced by increased membrane microviscosity; however, this interaction alone is insufficient to induce permeability-enhancing defects in the membrane.

Evelina Jankaitytė, Artu̅ras Polita, A. Sakalauskas et al. · 0 citations

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