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Author

V. Thiyagarajan

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Oct 2026

The identification of SiTRAF suggests the presence of a functional MyD88-TRAF signaling axis in the sea urchin Strongylocentrotus intermedius.

Tumor necrosis factor receptor-associated factors (TRAFs) are key signaling proteins involved in cellular innate immune pathways. However, knowledge of TRAF genes in echinoderms remains limited. We cloned a novel TRAF gene (SiTRAF) from the sea urchin Strongylocentrotus intermedius. The full-length open reading frame o...

Feng-Cheng Liu, Tong Liu, Xiao-Long Chu et al. · 0 citations
Aug 2026

Survival Costs Flavor: Microplastics Reprogram Metabolic Resource Allocation and Compromise Oyster Quality under Ocean Acidification

Findings support a bioenergetic trade-off in which oysters exposed to OA and MPs reallocate resources from nutritional and sensory quality toward cellular maintenance and stress adaptation, highlighting underrecognized consequences of climate change and plastic pollution for seafood quality.

Yi-Chi Ma, Meng-Hong Hu, V. Thiyagarajan et al. · 0 citations
Jul 2026

Scallop Toll-like Receptor Engages in Complex Interactions with Diverse MyD88 Proteins and Orchestrates Host Innate Immune Responses.

The identification of a novel TLR gene in Chlamys farreri and analysis of its immune functions expand the knowledge of the role of TLR in mollusk immunity and may provide evidence for selecting disease-resistant scallops for cultivation.

Jilv Ma, Feng-Cheng Liu, Zi-Hao Zhang et al. · 0 citations
Aug 2026

The versatile TRAF3 from sea urchin (Strongylocentrotus intermedius) interacts with MyD88 and regulates host immunity.

SiTRAF3 is identified as a pivotal scaffold protein in the echinoid innate immune system, as it significantly drove the promoter activities of nuclear factor kappa-B, activator protein-1, signal transducer and activator of transcription 3, along with multiple inflammatory cytokines and interferon-related elements.

Xiao-Long Chu, Feng-Cheng Liu, Yingying Liu et al. · 0 citations

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