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Open access Sep 2026

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization.

BACKGROUND Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP) is a modifiable risk factor for NAFLD and...

Yifan Hu, K. Smith-Byrne, Z. Bidel et al. · 0 citations
Open access Oct 2026

Mendelian randomisation identifies proteins with effects on multiple sclerosis and related traits

Background Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease with limited treatment options and frequent co-occurring conditions that complicate management. Genetic approaches can be applied to identify causal proteins and prioritise potential therapeutic targets across the landscape of MS...

Matthew Boyton, G. Khandaker, V. Walker et al. · 0 citations

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