With the introduction of window-of-opportunity trials, the demand for diagnostic brain biopsy surgery is expected to increase. In the context of limited neurosurgical bed availability, a Day Case Biopsy (DCB) pathway was introduced at Queen Elizabeth Hospital Birmingham (QEHB) in 2021 to provide a safe and effici...
Osama Elmoursi, Louis Taylor, Aimee Goel et al.· Neuro-Oncology· 0 citations
Diagnostic uncertainty represents a significant barrier to the timely initiation of treatment for central nervous system lymphoma (CNSL). Our previous 10-year retrospective service evaluation project demonstrated that concordance on multiparametric MRI (MPMRI) could be used as a radiological predictor of CNSL in...
George Phenix, Aimee Goel, Ute Pohl et al.· Neuro-Oncology· 0 citations
Glioblastoma is the most common and most aggressive primary brain tumour in adults, representing one of the most formidable challenges in oncology. Despite surgical resection, radiotherapy and chemotherapy, median survival rates are low (12-18 months) with fewer than 10% of patients surviving beyond five years. These...
Emma Welsh, Zhi Li, Jamie Cowley et al.· Neuro-Oncology· 0 citations
Integrated histopathological-molecular analysis is essential to diagnose and guide precision therapies in brain tumours. Whilst standard of care (SoC) diagnostics takes weeks, long read sequencing (LRS) on Oxford Nanopore Technology (ONT) platform and bioinformatics research tools provide rapid diagnosis within h...
Vassili Crispi, L. Ames, J. Stockton et al.· Neuro-Oncology· 0 citations
Brain metastases exhibit tumour-type specific metabolic reprogramming to adapt to the brain microenvironment highlighting distinct metabolic survival strategies compared to GBM, and supporting the need for tumour-specific treatment strategies.
Ishana Rajgopal, Bryan P. Marzullo, Sana Manan et al.· Neuro-Oncology· 0 citations
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