Vaibhava Lakshmi Ravideshik

ProtJEPA: A Multimodal Joint-Embedding Predictive Architecture for Protein Biological World Modeling with Multi-Teacher Modality-Attentive Fusion

Under realistic dark-protein deployment conditions where relational modalities are unavailable, ProtJEPA significantly outperforms naive concatenation of remaining modalities and cross-domain evaluations on drug–target interaction and disorder prediction confirm transfer beyond training modalities.