Motivation Genetically supported drug targets are an estimated 2.6 times more likely to succeed clinically, yet a disease association alone does not show which protein to target, in which direction, or what other effects may follow. This currently requires chaining separate tools. Results drugMR is a Nextflow pipeline...
G. C. Cimadevila, Marie-Joe Dib, M. Bracher-Smith et al.· bioRxiv· 0 citations
A brain maintenance mechanism that supports the brain's ability to resist to changes in neuronal integrity is suggested, suggesting a brain maintenance mechanism that supports the brain's ability to resist to changes in neuronal integrity in Alzheimer's disease.
G. Leonenko, K. Mavromati, Lynn Hughes et al.· Annals of Neurology· 0 citations
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
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