Valeria Fumagalli

Gapmers targeting conserved SARS-CoV-2 single-stranded regions reduce viral load and reshape inflammatory macrophage responses

Summary The COVID-19 crisis is now over, but additional viral strains of SARS-CoV-2 that evade immunity are continuously emerging. We explored the design, evaluation, and optimization of anti-sense oligonucleotides (ASOs) targeting SARS-CoV-2 RNA, with the aim of providing a scalable strategy capable of responding to e...