Open access
Aug 2026
A conserved serotonin receptor pathway is a druggable modifier of Tau pathology, neural circuit formation and neurodegeneration
A new Drosophila tauopathy model expressing eGFP-tagged human TauWT or the disease-associated TauP301L variant in the nervous system is established and 5-HT7R signaling is identified as a conserved and druggable modifier of Tau toxicity.
Mariana I. Tsap, Valeriya V. Navrotska, J. Labus et al.
· bioRxiv · 0 citations