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Author

Valquíria Silva

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Open access Sep 2026

Spheroid maturation determines drug response and establishes a mechanism-informed framework for analytical endpoint validation in three-dimensional lung cancer models.

The limited predictive value of conventional two-dimensional (2D) cell culture models remains a major obstacle to successful anticancer drug development. Although three-dimensional (3D) multicellular tumor spheroids better reproduce key structural and functional features of solid tumors, standardized methodologies and...

Jéssica Eduarda dos Santos Batista, Valquíria Silva, F. B. Carvalho et al. · 0 citations

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