Vanessa Kabbouchy

Extracellular GPX3 drives insulin receptor expression in adipose tissue independent of its peroxidase activity

Obesity-associated insulin resistance is driven in part by adipose tissue dysfunction and oxidative stress, yet the role of extracellular mechanisms in modulating insulin signaling remains poorly understood. Here, we show that extracellular Glutathione Peroxidase 3 (GPX3) enhances adipocyte insulin sensitivity and func...