Varun Sundarkumar

Enhanced Scale-Up of Rotor-Stator Wet Milling Using Population Balance Modeling with a Novel Exponential Shear-Activated Kernel

Wet milling is a critical operation in drug substance manufacturing, enabling control of the particle size distribution of active pharmaceutical ingredients. Scaling up of the wet milling process usually involves equipment change. Due to material availability limitations during the early stage of development, there i...