This narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in apolipoprotein B-100 is considered, and the enzymes of the sialid...
Tatyana I. Kovyanova, V. P. Karagodin, D. Borodko et al.· Biomolecules· 0 citations
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide, driven by complex interactions among dyslipidemia, chronic inflammation, insulin resistance, endothelial dysfunction, and gut microbiome-derived metabolites. This review synthesizes mechanistic and clinical ev...
Tatyana I. Kovyanova, M. Nerush, V. P. Karagodin et al.· Biomedicines· 0 citations
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